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KMID : 0613820120220060772
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Journal of Life Science
2012 Volume.22 No. 6 p.772 ~ p.777
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Effects of Black Garlic Supplementation and Exercise on TBARS, HSP 70 and COX-2 Expression after High-intensity Exercise
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Baek Yeong-Ho
Lee Sang-Ho
Han Min-Ho
Choi Yung-Hyun
Kim Seung-Hyun
Kwak Yi-Sub
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Abstract
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The purpose of this study was to investigate the effects of black garlic supplementation and exercise on TBARS, HSP 70, and COX-2 expression after high-intensity exercise in rats. Twenty-four male Sprague-Dawley rats (4 weeks) were used in this study. Experimental groups were a control group (A, n=6), black garlic supplementation group (B, n=6), exercise group (C, n=6), and black garlic supplementation with exercise group (D, n=6). High-intensity exercise was performed by treadmill running (every 10 min speed increased gradually; 15~24 m/min, 0℃ grade) and 2.86 g/kg black garlic for 4 weeks. The findings of this study were as follows: TBARS levels were significantly lower in the D group compared to the other group and B and C groups were significantly lower in TBARS levels than in the A group. HSP 70 expression was lower in the B group compared to the other groups. COX-2 expression has showed a similar expression in all groups. Therefore, it is considered that black garlic intake and exercise may reduce oxidative stress.
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KEYWORD
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Black garlic, TBARS, HSP 70, COX-2
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